I would recommend against a hybrid drive, not really worthwhile.
If you have the budget to get a large enough SSD to put your OS, programs, files, and games on it, then its fine to use a single drive.
However, its more likely that you are going to need more storage than is affordable (*though, SSD prices are dropping). In that case, I would recommend an SSD for the OS, programs, and some games. HDD for your files, large games, etc.