So 3 x34 predator setup

[Ampzx]

Do I run 2 1080gtx in sli or do I run 3 of them one for each monitor?

 

[Hlsgsz]

Do I run 2 1080gtx in sli or do I run 3 of them one for each monitor?

Two in SLI. You can't game with separate cards driving separate monitors.