(PCPP is down so I can't give you a full build ATM)
If your software is very single threaded heavy, then I'd start with this:
Core i5-9600K
Asus Z390-A
GTX 1650 or GTX 1050 Ti.
Because GTX cards can't support six monitors, you'll want to plug two or three of your monitors into the motherboard so that the 9600K's IGPU will be used, then plug the rest into the dedicated graphics card. (Oh and in the BIOS you'll want to set the IGP to dual monitor mode)