TRIM still works for Intel Rapid Storage Technology. I'm currently running two SATA SSD's in Raid 0, and can confirm that Windows 10 reports that it is able to trim the drives ('Optimize' instead of defrag). As far as I know, the NVMe drives operate in the same fasion.
P.S.- There's some debate as to whether or not you'll really notice anything other than transfer throughput. IOPS will technically be higher, but if you're operating normal desktop user/client stuff (gaming/browsing/etc) and not running databases and stuff, you will not see an improvement in performance. Most desktop client/user environments don't exceed a queue depth beyond 2. You'll need to hit 8+ on your queue depth to really benefit from the increase.
Also, your boot time will be slightly longer as the RAID ROM will have to load before the OS.
You do however gain the convenience of having one storage volume instead of two. However, you also gain increased risk of failure (Raid 0)- if one drive fails, you lose all the data on both.