You can use them, as long as they are powered. Sound good, although they take up a lot more desk space than a regular 2.1 setup. I have M-Audio AV30 in the bedroom, sound amazing, although they are not very "high end". AV20 should sound the same and be cheaper, they look to use the same exact cabinet and speakers as the 30s. To get about the same quality in Logitechs you'd want to get one of their THX certified speakers, their other models are good, but lack a bit clarity and punch compared to the higher-end series.