richard.b.mcintosh :
bjornl :
You aren't going to get 4 1080tis on that motherboard as several of the slots are too close together for that. The cards are 2 or 3 "slots" wide.
More cores CPU might help more than more video cards.
SSD vs HD makes little difference to render speeds. SSDs are faster. I would suggest an M.2 type drive for boot. A fast SSD for projects and several large disks in a mirror (or raid if you have a hardware raid controller) as backup.
If I were building a new render box, I would look at one of the newer i9's. 44 pcie lanes, lots of cores,
Can I fit GTX 1080s? Or what would be the best GPUs I could fit? I've seen many quad GPU setups online but know very little doing this
Not stock 1080's. Look at the cards and look at the slots. The cards are almost all 2-3 slot solutions. Meaning that you might get 2-3 cards in most mother boards at most. You can increase this number by using very thin (and slightly complex to set up) water cooling.
If you are trying to duplicate a particular person's build, have you thought about asking them for their selection of parts and if they have any advice? Most people love to share their builds.
Are you a very experienced blender user? If not, I strongly suggest you start small. Blender is not like other 3d apps. It is more or less an acquired taste. Those who use Lightwave, Maya, Studio Max and Cinema 4d seem to be able to move from app to app. I don't know alot of guys using those tools who moved to Blender. Similarly I don't know a lot of former blender users using more main-stream apps.
Consider building your PC carefully for expansion.
Get a newer system based on the i9 series. For example the i9-7940x
Get a very nice motherboard such as the GIGABYTE X299 AORUS, with lots of expansions (includnig 5x pcie x16) and good build quality. The asrock fatal1ty x299 professional gaming is the only one I know that support 4 video cards (but the slot layout makes it hard to go over 3).
Get a very nice power supply (very efficient, reasonably high 80+ rating (gold or better) .
Also on power, get a nice UPS.
I would not bother with 3000mhz CL-15 ram. I'd suggest CL14 ram. Both Kingston and Corsair make nice modules with lower latency. Remember the ram won't run at 3000mhz unless it is set to. By default a 6850 will run its ram at 2133 or 2400 depending on the motherboard and selected ram. The i9 will only run it at 2666. A little room for overclocking is nice. But unless you are very geared towards that, I would focus more on latency than clock rate since you will always enjoy the lower latency and only enjoy the higher clock rate if you go there (OC).
I would also consider getting 64gb of ram, but 32gb should be plenty.
Also get 4 sticks of ram.,
Storage. Go BIG! 3d project files can explode in size. I would recommend the following:
a nice fast m.2 boot disk. A nice large SSD for loading your application and current project from. A pair of really large drives in a mirror to backup to. I would suggest NAS or enterprise rated drives. I particularly like HGST. The reason for this type of drive is that they are more robust. The disks are less likely to fail. The reason for the mirror set is because they still do fail and you don't want to lose your entire catalog due to a single point of failure. it is still a good idea to also backup to either the cloud (something like Adata) or a NAS device located in another part of your house.
I suggest you start with air cooled video cards and go with either just one or two.
I'd suggest the 1080TI because it has more cuda cores, and is generally much faster than the 1080 for your uses.
Get a nice wide case (I really like Fractal design's Define R5).. Wide cases have more air in them and so tend to be more thermally stable. Also this particular case is very quiet even with a lot of disks in it.