You don't need to uninstall drivers, but it won't hurt to. All you have to do is take it out of the motherboard POWERED OFF AND UNPLUGGED. Make sure you have all static discharged. Take it out and connect it to the new PC before the first boot. Then, boot up the PC. Go to NVidia.com or AMD.com to download the drivers for the card. You could also just use a driver disk. Then, use it as you normally would. If any questions arise or if any problems appear, feel free to tell me or ask.