It prevents me from clicking on anything within the area of the box, whether in a video game, on the desktop, using an app, doesn't matter. It's like a dead zone. This pic shows where I'm unable to click anything.
I checked task manager and nothing is open that I don't have control over. It fixes itself if I restart my PC, but that's inconvenient when in an online game. It happens randomly, but it does seem more likely when I slam the windows button a few times, to get out of game and to the desktop for a sec.

I checked task manager and nothing is open that I don't have control over. It fixes itself if I restart my PC, but that's inconvenient when in an online game. It happens randomly, but it does seem more likely when I slam the windows button a few times, to get out of game and to the desktop for a sec.