I've used every combination of Intel, nVidia, AMD, SiS, VIA/S3 and ATi (except Intel Graphics of course..lol). They're all plug-and-play. It's like worrying that a Seagate HDD won't work as well with an Intel CPU as with an AMD CPU as opposed to a drive by Western Digital. Anything anyone has ever told you to the contrary is pure crap. Believe me, nVidia probably hates Intel more than they hate AMD. They know just like everyone else that if AMD ever falls, the whole industry is in trouble because Intel will turn it into their own version of North Korea.