Crossfire is putting two video cards into one computer.
Personally I don't think over-clocking is worth it. It shortens the lifespan of the product (either CPU or GPU) because they run hotter. Sure, you get 10% or 15% more performance, but so what? The only over-clock I've ever done is on my i7-4770K Haswell CPU, and even then just a little bit. I do a lot of video re-encodes of recorded TV shows with Handbrake, it produces a file about 50 - 60% the size of the original file, and it can take up to 90 minutes to encode, so by giving my CPU a little boost I can cut 10-15 minutes off the encodes. What's nice about my Haswell 4770K is that the overclock doesn't effect it most of the time, it just boosts the top frequency, so that when pushed, such as during a video encode, I get higher turbo frequencies, but the rest of the time it runs normally.