Twice as much memory in one dual-channel, or half divided on two dual-channels?

[XistenZ]

If I have a motherboard with 4 slots (as most have), that only supports dual-channel but not quad-channel, and if I want 16GB total, what would be more beneficial?

2x8 (utilizing one dual-channel)
4x4 (utilizing two dual-channels)

The answer to this question is of course applicable on any given amount of GB, it was an example. No need for posts like "you don't need 16GB, just use one dual-channel if you're unsure".

 

[theyeti87]

Since there is only dual-channel support, I would go with the 2x8GB config. That leaves you with two open RAM slots for the future if you wish to add more.

Also, there's half the number of sticks, so relatively 50% less of a chance that one stick may die.

 

[Traciatim]

theyeti87 has some good advice. There really isn't a whole lot of practical difference between using 2x8 or 4x4, but one option has the ability to leave slots open for later expansion and the difference in price isn't likely to be tilted very much either way so you may as well leave your option open.

 

[InvalidError]

The CPU has two DRAM channels regardless of how many DIMMs you use.

Having one DIMM per channel uses less power, is usually cheaper, eliminates most chances of compatibility issues and gives you the option of adding more later.

 

[Ubrales]

I'd go with the 2x8GB because data transfer will be more efficient than 4x4GB. Also, as others have stated, 2 RAM slots will be available for future expansion.

I have 4x8GB Corsair Vengeance modules (max that my motherboard will support) and I still experience lags while rendering.