Yes it will run it GREAT! I have the asus rog pg348q which is the exact same monitor as the x34 acer and i ran bf1 all day yesterday with sli disabled only using 1 gtx 1080 and was getting a consistent 100fps with 88fps being lowest. This was with max settings. Of course games will vary for instance in division (which is a shitty optimized game) i get like 60-70 fps. So yes a single gtx 1080 will be fine