1) Can you boot into SAFE MODE from the W10 disc?
2) If still stuck, I think you can reinstall W10 over top of itself. I've only done this from within Windows.
http://www.tenforums.com/tutorials/16397-repair-install-windows-10-place-upgrade.html
1) Boot to W10 install
2) do NOT enter a key when prompted
3) choose to UPGRADE
4) make sure it's the SAME version (i.e W10 Home 64-bit).. you may have multiple versions (or just W10 Home 64-bit and 32-bit)
5) choose to keep programs and data
3) run a Memory diagnostic with "memory diagnostic" (launched from Windows). I prefer Memtest86 www.memtest86.com and would do that BEFORE reinstalling Windows. Make disc/USB on another PC.
About 30min per 8GB to do the full test. Errors may indicate:
- bad memory
- BIOS setup issue
- memory not fully seated
This is likely not going to affect your video card issue, but you should test your system memory at least once as you can get data corruption if it has problems.
4) may have a UEFI compatibility issue with your video card. That's pretty common. May need to change BIOS settings, but that MAY require a reinstall of Windows.
There is a section called "CSM" or Compatibility Support Module that may have issues if the new card vBIOS needs UEFI but you are set to Legacy.
https://en.wikipedia.org/wiki/Unified_Extensible_Firmware_Interface#CSM_booting
I don't completely understand all of the issues here.