There is a very good possibility it won't work. The E5200 is a 45nm chip, and the Q6600 is an older 65nm chip. Get the manual for your computer online and find the supported processor page. The Q6600 requires a lot more power than the E5200 and the motherboard might not be able to provide it. Be sure you have the latest BIOS update as support for newer processors is added that way. Most likely Quad is Q9550/9650 or Q9505. there are also very low power Q9505s, and Q9550s chips that draw about the same watts as a dual core. See if they're supported.