I am no expert, but the cooler the air being sucked into your heatsink, the more heat it will take with it when it goes. You'd have to suss out the best airflow setup for your system and where it's located. I take the easy way and locate my box where there is good airflow, replace windows in the case with mesh, or add large mesh panels, and concentrate on pushing out the hot air that is exiting the CPU heatsink. I figure with an open case and strong exhaust, the air is going to find its way in. I live in a very warm area, so it's easy to hobble the whole system by filling the case and its immediate environs with hot air.