You can try the USB wake settings on the board. It is just generally the way systems are now with power on usb when the system is in standby mode(ATX power supplies are never fully off without switching it off at the back or unplugging it.).
If you wanted to make a DIY setup, you could modify a pci plate usb -> 10 pin adapter to take power off of the computer power supply. This would cut usb power on standby.