USB ports in the back of PC randomly disable

[ShevyPri]

Hi, I'm having a problem with my PCs USB ports... My motherboards USB ports randomly disable. I have a mic, keyboard, mouse, and speakers plugged in, but it seems like my PC only wants to read two at a time. The front USB ports, however, always seem to work. This all has been happening out of no where since I've installed my speakers and mic on my new monitor. I'm not sure if they have something thing to do with it... Also, my PC struggles to find an input when I restart it sometimes to the point that I have to keep unplugging and replugging the DP cable until eventually I get some sort of signal (not sure if that has anything to do with my USB problem).

 

[Lutfij]

Is it possible to pass on your full systems specs inclusive of your OS, peripherals and connected devices? Are you sure your BIOS and device drivers are up to date? You could rule out a faulty powersupply by borrowing a similarly spec'd yet reliable unit from your friend and seeing if the issue is replicated.

Have you ruled out if some of your ports are faulty or all of them? i.e which 2 are prominently detecting your devices?