Using DDU with AMD GPU/APU

A friend of mine has some problems with the drivers on his AMD GPU (I forget which one - it's an R9 series card) and I want to use DDU.

I've never personally worked with an AMD based chipset system before. Considering that he has an AMD system (with an AMD recent FX-series APU) and that AMD systems don't have integrated chips to run on while I uninstall the GPUs drivers, will everything be okay until he reinstalls the driver that he needs?

Considering how popular DDU is, there shouldn't be any problems (I would assume).