I'm guessing a HARDWARE issue, not software.
I recommend doing these things immediately to start troubleshooting:
1) Shut down and remove VIDEO CARD. Then attach monitor to motherboard (to use iGPU in Intel CPU) and start., and
2) Test System Memory using MEMTEST. www.memtest.org (run from USB or DVD... change BIOS boot order as appropriate or it will just boot into Windows. i.e. if using DVD then the DVD drive must be first, then Windows drive second)
3) run CPU diagnostic:
https://downloadcenter.intel.com/download/19792/Intel-Processor-Diagnostic-Tool-64-bit-
*If you remove the video card and the issue disappears it can also indicate a DRIVER issue (AMD), or possibly even a failing power supply due to less load but at least we narrow in on the issue. If you still freeze just put the card back in.
MEMTEST should run a full pass. It just validates the DDR3 memory (physical sticks next to CPU).
The INTEL CPU diagnostic may indicate a problem if there is bad memory since it gets its data from System Memory. i don't know if it has a way around that (by switching memory locations for bad results) so if it fails then make sure to test MEMTEST first.
OTHER TESTING:
Reinstalling Windows is one option. Another option is to run Linux off a DVD though I'm not sure if your issue happens enough to make troubleshooting easier. If you have a SPARE hard drive then I'd recommend installing the latest W10 Preview and simply unhook the current one to make things easier.
If software is corrupted in Windows 10 that can happen due to a number of things (memory, motherboard, power supply, HDD/SSD... ) so reinstalling Windows may work in the short term but if there's a hardware issue you'll get the problem back.