2D is your desktop, and most business software. The video card just idles to draw these screens. A lot of video cards will run at 135Mhz doing 2D work.
3D is 3D games, things that are fully graphical and where the GPU has to actually do some serious work to generate the hundreds of thousands of pixels 60 times a second to produce the illusion of motion on the screen. Most video cards today jump up to 1Ghz and higher to do 3D work.