Adding installed programs that these days, practically all want to have some kind of process that resides in memory.
Viruses, malware, trojans and other infections.
Running out of drive space on the drive the OS is installed on. This can be for many reasons but a few common ones are accumulation of temporary files, Windows.old folders from major Windows spring and fall updates or excessive personal and downloaded files and folders that are bringing your total on the drive near it's capacity and should be moved off to a secondary or external drive. (And then backed up to another location so they are not lost if that drive should happen to fail)
Leaving System restore enabled. (Which is lame, because it never works right when you try to use it for recovery anyhow. You are much better off taking snapshots manually using a third party program like Macrium reflect or Acronis True Image, and not allowing them to run except at a time of your choosing. I tend to make a backup periodically but I disable System restore immediately following a clean install OR performing one of the major Windows spring and fall updates that generally turns it back on.)
There are some things here that you can try, that should probably be done as a regular maintenance routine anyhow.
If you are looking to clean up Windows 10 after an upgrade or clean install, or just as a good general maintenance priority, there are some things you can do to streamline operations and remove unwanted junk. Most of it is pretty standard, similar in nature to previous versions of Windows but...
forums.tomshardware.com
In addition, if you do not have an anti-virus/malware scanner, I would either get one or make sure that Windows defender has fully up to date virus definitions (DO this as well, if you have a 3rd party virus and malware utility) and then run full scans of all connected drives. If nothing turns up, it might be a good idea to run a "second opinion" scanner as well. You can find some general guidelines on this here:
Below you will find not a highly technical How-To, as there are plenty of those across the web, but instead an easily referenced resource for less technically astute members or visitors who simply want easy provision of resources related to the discovery and removal of infections in a variety of...
forums.tomshardware.com