The fastest way would be to format the drive and do a clean install of everything. Short of that you will need to uninstall the programs you don't use and manually delete the files you don't want to keep. Removing the folders from Programs Files without first uninstalling the programs will leave your registry in a mess. If the files in question are personal files you could simply delete the folder containing those files. You will not want to delete the parent folders Documents, Music, Pictures, Video) under libraries. You should be able to delete the folders you created without any harm being done.