Its not really a big deal, just make sure you screw down the sides will be getting most activity like the PCI openings on case, middle of board, and memory slots, since once and a while you be pulling those out (you don't wanna pull the motherboard up when pulling those out). So I guess don't use the bottom middle or bottom corner screw (just go to your local computer store and get some more screws)... At least that's what I've done in the past.