If you have a choice of two drives with the same capacity, go for the one with the fewest platters for the reasons elucidated above.
But it's common for manufacturers to sell a series of drives with the same platter density with one, two or three platters per drive. For example, a drive series with platters that hold 500GB might be available in 500GB, 1TB, and 1.5TB sizes. If you're looking for the best performance, you should buy the drive with the highest capacity (the 1.5TB drive with 3 platters).
The reason for this is that 500GB is spread across all of the tracks of the 1-platter drive, but the same 500GB can be fit into perhaps only 1/4 of the outermost tracks of the 3-platter drive. This means that you'll do a lot less seeking to access 500GB of data on the larger drive.