They all make different sized rads, most of them have a slim or what i would call standard thickness. Etc. like most AIO 240mm watercoolers thickness.
Then there's the ones that are about x2 and x3 times thicker, the thicker the rad is, the better it cools because of more surface area and the lower the restriction of the waterflow will be too.
Though most people have a hard time fitting the super thick rads, the mid-thickness one is a good solution between performance and compability, you're also going to pay more for the thicker rads. The thicker the rad the harder your fans will have to push air through it too, keep that in mind.
Etc. the Corsair H80i AIO watercooler features a 120mm rad but still almost achieves results on line with...