hello... typically... ATX motherboard is largest... uATX ( mATX ) is smaller... less slots to plug in things, but will also fit in a ATX motherboard Case. There are uATX motherboard only cases.
You want to find a case that will fit a Standard Size ATX power supply. So replacements will be common in the future.
And like Scout_03 said above... High end graphic cards can be very long... and the location of the PCIE slot on the motherboards, in relation to the case, can very... and you can have obstruction with a Smaller case "Drive Cages".