Define "best"
A 4 stick kit will still operate in dual channel mode.
But, because it costs more to match 4 sticks vs. 2, a 4 stick kit will be more expensive.
Then, the matter of speed.
It turns out that faster ram is accompanied by higher latency, negating the benefit.
Here is a report on skylake ram scaling:
http://www.silentpcreview.com/article1478-page1.html
Fancy heat spreaders are marketing, simple low profile ram works equally well.
Lastly, from my overclocking experiments, I found that the added voltage to run ram faster than 2400@1.2v seemed to take away my overclocking headroom.
A 2 x 8gb kit of 2400 speed would be my vote.
Lower latency is better; look to Corsair lpx.