It's perfectly safe.
It may cause some stuttering depending on your CPU, the game and what priority the game and backup utility are set to. For example, a "LOW PROCESS" is ideal for the backup so if your CPU is needed it won't affect a "HIGH PROCESS" which your game is hopefully set to.
I've had backup kick in when I'm gaming. No issue. It's never affected my experience for any game (i7-3770K + GTX680).