Patrick is absolutely right that the faster and lower latency memory is better all else being equal... no question. But if you're paying a lot extra for the faster memory, you're likely to be better off investing your money elsewhere. Faster RAM doesn't make a huge difference, so if buying faster RAM leaves you less money for something like an SSD, or reduces your GPU budget, I'd go cheaper RAM myself. But no doubt, if they're priced similarly it's a no-brainer.
Just a quick note on the 2x8 vs 4x4 question. If you're on a dual channel platform (non "extreme" processors on the Z99, Z170 motherboards, etc), 2x8 is definitely the way to go. If you're on a Haswell-E or other quad memory channel platform (X99 motherboard with a 5820K/5930K/5960X), then 4x4GB will in theory give you slightly faster memory, because the system can access all four channels at once. Again in the real world it's rarely noticeable, but on a pure performance basis 4x4GB will give you faster memory if (and only if) you're on a quad channel platform like the Intel-E gear.