Full nightly backups. Maybe distribution/cloning of large RAW video files. About the only 'small scale' operation I can think of that would benefit.
I still do direct drive installation for backup. Just plug a drive in, back it up overnight and put it back on the shelf.
Haven't done anything to my gaming rig in a while, so it is static with cloud backup for the currently installed games. Just swapped the main drive of my HTPC to NVMe, so I have fresh snap shot of the pre-upgrade on a SATA SSD.
Actually now in a position to have one of my machines act as the host of an NVMe drive exclusively for backup purposes (both also 2.5Gbps equipped). Would be kind of nice to have like an 8TB QLC drive with all of my OS clones on it for fast retrieval. But every time I think of doing it, I realize that the potential downtime has so little impact on what I do with my PCs. 95% entertainment at this point. Long as I have my personal files backed up, everything is replaceable.
Also still need to figure out a decent way to get an ethernet cable over to the modem. Most inconvenient in my house. All the wiring in my office goes through the ceiling/wall. And the living room is most easily accessible from underneath. So I have to fish something through an entire vertical wall somewhere...