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Question Which M.2 slots to use

Nov 26, 2023
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I'm building my system and am a bit unclear on which M.2 slots to use on my motherboard (this is my first build using M.2 drives). I have:

AMD Ryzen 7700x CPU
Asus Rog Strix x670e-f motherboard
Two M.2 drives, both Samsung 990 Pro (a 1TB drive for OS/apps, a 2TB drive for games)

The motherboard lists the four slots as follows:

AMD Ryzen 7000 Series Desktop Processors:
  • M.2_1 supports PCIE 5.0 x4 mode M Key design and type 2242 / 2260 / 2280 storage devices
  • M.2_2 supports PCIE 5.0 x4 mode M Key design and type 2242 / 2260 / 2280 storage devices
AMD X670 Chipset:
  • M.2_3 supports PCIE 4.0 x4 mode M Key design and type 2242 / 2260 / 2280 / 22110 storage devices
  • M.2_4 supports PCIE 4.0 x4 mode M Key design and type 2242/2260/2280 storage devices
Which slots does it make sense to use in my situation, and why? Obviously the drives are PCIE 4.0, so that is not a factor, but I was wondering if there was any other factors I should be considering?