For a system using a single GeForce GTS 250 graphics card NVIDIA specifies a minimum of a 450 Watt or greater system power supply that has a maximum combined +12 Volt continuous current rating of 24 Amps or greater and that has at least one 6-pin PCI Express supplementary power connector.
Total Power Supply Wattage is NOT the crucial factor in power supply selection!!! Sufficient Total Combined Continuous Power/Current Available on the +12V Rail(s) rated at 45°C - 50°C ambient temperature, is the most critical factor.
What is the brand and model number of the 420 Watt power supply unit?