The GTX645 was a gutted OEM version of a GTX660. It's a 65W card so if it fits it should run.
You can scroll down here and see it's relative performance to newer cards.
https://www.techpowerup.com/gpu-specs/geforce-gtx-645-oem.c2359
But newer 65-75W CPUs perform much better. GTX750TI, GTX1050, GTX1050Ti. Even the 37W GT1030 outperforms it by quite a bit.