It'll run perfectly.
FYI my new rig (in avatar) runs my 'old' and much abused HD7950 flawlessly.
Few points.
Once the build is up and running, consider checking for BIOS updates, but don't install one unless there is problems.
Good as it is the GTX680 is getting 'old', if you don't already, keep an eye on graphics card developments through tech sites, you'll be well informed when the time comes to upgrade.
Get a MB which has an integrated graphics output, they're really handy for troubleshooting.
Don't go cheap on the power supply, quality is more important than claimed output.
Even if you're going to stick to stock speed, adding a inexpensive CPU cooler like the Coolermaster Hyper 212 Evo into the mix is a good investment, it'll be cooler than the stock item and quieter.
Strong systems need good ventilation, so look for a case with at least dual 120m.m. front intake fans and put good ones in there, supplied fans are often less than top of the line and a pair of Corsair AF120 Performance Edition (or similar) will not only improve cooing but help to keep the noise down.
If you have cats or dogs in the house get a case with filters for the intake fans. I've several cats and when they shed the little darlings can quickly clog my air filters-be warned.