Im running crysis patch 1.2 and a whole load of vista updates and patch's. Video driver version make a big difference, the december version seemed to have stability issues Im running the march version now and having less problems, thats for my 8800GTX.
I find vista a pleasant enough experience for gaming, dx10 can make a decent difference in some games, I find the enhanced shadows added via dx10 to one game I play to be a particularly nice addition. Well worth the upgrade, and when all patched up I have had no issues with vista 64 bit, apart from lack of drivers for my colour laser printer