If they even play together they will initially run at the mobos default, generally 1066 or 1333, then it's up to you as to what freq you set them too...it's not whatever the slowest DRAM is, i.e. you have a 1866 and a 2133, they still go to the mobos default, they won't automatically run at 1866....and again, that's if they even play nice together