The CPU and cooler will fit, but you may need to do a BIOS update to get the board to work with the CPU. If you already own this board, then you should update the BIOS before your put the new CPU in. If you don't own this board, then it's luck of the draw on whether you get a newer board that already has the BIOS for the 2600, or if you will need a 1st gen Ryzen CPU to do the BIOS update.