My reading of the specs say yes, you are supported.
You may need to install the samsung pcie nvme driver.
Worth is something only YOU can decide.
The advantage of a pcie drive is faster sequential performance.
But, most of what windows does is small random I/O and performance there is no different than a sata drive.
I made such a change and about the only time I noticed a difference was in antivirus scans.
I think such a change should be accompanied by an increase in ssd capacity to be worth it.