Do you now have all of the above parts?
I see no issue on running any graphics card on that motherboard/spu combo.
With your obvious budget, I would suggest the i9-11900K instead.
While it has the same number of threads, it is a better binned chip which will OC or turbo up higher.
You have a number of samsung 980 PRO m.2 pcie devices.
I think there will be limits on running all of them at pcie 4.0.
And some sata ports will be disabled.
Read the motherboard details to see exactly what.
If you need a lot of storage, look at a 2.5" 8tb samsung 870 QVO to replace the 2tb HDD.
I don't think the corsair obsidian 500D case has provision for a 5.25" player.
The case is a good one for air cooling.
I have no problem with heat using a...