A clean installation of Windows 10 should be fine. Windows 8.1 drivers for your network adapter, the latest chipset drivers, and the latest generic Realtek audio drivers from the Realtek website (http://www.realtek.com.tw/downloads/DownloadsView.aspx?Langid=1&PNid=24&PFid=24&Level=4&Conn=3&DownTypeID=3&GetDown=false) are all you need to make the motherboard work correctly. I personally run an X58 motherboard that's far older than your Z68, and I have no issues.