There are two issues.
1. Do you need to do a clean install?
If your motherboard chipsets are sufficiently similar, you can boot with your os drive and simply install the new chipset drivers that came with your new motherboard. The odds are a50/50 that this will work.
If you need a clean install, use windows easy transfer to export your files and settings. After the install, you can import them back. If you are not using a ssd, consider this as an opportune time to install one. On a clean install, you will have to reinstall your programs.
2. Windows activation.
If your windows is retail or upgrade, no problem. If it is oem, the license is tied to the old motherboard, and you need to buy a new license. ... in theory...
MS is surprising lenient about letting you reactivate with a replacement motherboard so long as you tell them that this copy is used nowhere else. It is worth a try.