https://answers.microsoft.com/en-us/protect/forum/protect_defender-protect_scanning/windows-defender-wont-turn-off/393d47ea-761f-435f-8c53-20e2f7e6de3dThis is security feature of Windows Defender and if you turn it off for a while, it will re-enable .
Normally, if you install another Anti-Malware product, it should take over as default Anti-Malware product and it will turn off Windows Defender.
If this doesn't happen after you install ESET, probably the version of ESET that you are using is not compatible with Windows 10 or there are other technical issues and you may contact ESET support to discuss this issue.