If I would benefit, how would I do it?
the biggest benefit from it that i've found is having things more easily organized and separated in case of drive or OS failure.
one example is backups can be completed much easier.
having your OS and applications separate from your personal files(media, text, work projects, etc) can make this an easier task.
if you have intermittent disk backups occurring regularly there will be less data on an OS\apps drive than if it also included large amounts of personal data and vice versa.
and having these backups separate when looking to restore one of them keeps you from having to wipe\replace all OS & personal data at once.
also if you have a case of OS corruption or just want to reinstall you won't have to worry about backing up and replacing files if they're already stored on a separate drive.
i currently have ~3TB of games installed and if i had to relocate & restore or reinstall them every time i wanted to install\reinstall the OS it would be quite a hassle.
so having them on a separate disk makes this much easier.
i also keep a separate drive for downloads, temporary files, and other quick projects to keep the drive wear down on my main drives and to also have these files separated in case of OS problems appearing while in the midst of something.
this way i can usually pick up where i left off without losing the data due to OS failure.