Big question is what CPU first and second what mobo? With a strong 8350 or 8370 you can prob run 2400, a CPU OC will prob be required. Most AMD mobo use DOCP (the favored flavor of DRAM OCing, and others use EOCP, some use XMP and some use AMP. DOCP and EOCP both read the XMP info from the SPDs of the sticks and then are programmed to assign timings per their BIOS programming, I.e. the Crosshair Formula under DOCP takes 2400/10 DRAM from it's XMP profile (10-12-12- 31) and configures to it to 10 (or 11) -13-13-35. For most folksw/ a 8350/70 I recommend up to 2133/9 as a max