if it doesn't run in vista, it will not run with windows 7, how ever, for some XP apps u can run it in XP mode (not compatibility mode but a feature for windows 7 professional and ultimate) this is just a VM of XP thats included but will run the program out of the VM and as if it were a normal windows but with the XP window boarder, though this dose not work for directX applications, though any apps like that should get a update so it will work with vista/windows 7 when 7 comes out, if not its not worth using as it is out of date to much and there is likely a program to take its place that will do a better job