Many setups are more about looks and when i look at them you just go facepalm. I just have 2 200mm at front and 3 120mm at rear. Dont fall for the negative pressure and postive pressure "science".
Apart from the AIO, the motherboard needs cooling- particularly the VRM and chipsets. The wonderful people at ASUS thought it was a good idea to not include a large mass heatsink with sizable surface area for my chipsets, so they sit at 81degrees at toomtemp at idle. No room for typical heatsinks as the GPU is enormous but they not smart enough to design a different shaped heatsink. So this is where cross breeze from front to rear helps but needs alevated fan rpm, better to just turn down current flow in power managment, cant see any performance loss. The motherboards today get very hot and need a strong cross breeze with a wide high volume of air and so many setups out there are just not gonna do that. That is why i went a large case with big fans as my system is overengineered and will cope easily.
With powerful cpus the motherboard also conducts some of the heat away.
My 4080 has such large heatsinks that a gently cross breeze is very suffiecent at keeping it cool with the three fans blow down combining into the bottom air stream exhausted out the back lower 120mm.
If the AIO is being exhausted to the top this can interfere with the cross breeze especelly if thye volume/capacity is small like on medium sized cases. I use an air cooled cpu cooler, it has a medium size mass and the cross breeze is abstructed by the rgb strimer, but yet it still easily performs well over 90% as good as the best water coolers.
So large pc case means a stable system that is cool and reliable.