There is no guarantee. It may work, but it may not. Using 2 sticks of RAM on the same channel will change the electrical characteristics of the channel enough that if the RAM has no issues working side by side at the 1600 speed, the 1600 ram might not want to overclock as fast as it could otherwise... even to the point of not being able to overclock at all. Without knowing more about the RAM, the best (and it may still be the best, even knowing the RAM, MoBo, and CPU involved) I can say is, you have better chances running both at 1600 than overclocking to 1866.