I'd actually argue against using less DIMMs over more DIMMs.
It is true that more DIMMs put higher load on memory controller on MoBo, but after all, when MoBo memory controller couldn't handle running 4x DIMMs at the same time, MoBo wouldn't have 4x RAM slots to begin with.
As of why running more is better - response time (less latency).
In a 2x 32GB set, it takes CPU longer time to access data in the back end of the RAM, compared to 4x 16GB.
E.g in 2x 32GB set;
***************************data****
***************************data****
------>-----time in ms------->------
vs 4x 16GB set;
**********data****
**********data****
**********data****
**********data****
------>-----time in ms------->------
And when to compare two sets of RAM;
link:
https://ram.userbenchmark.com/Compa...engeance-LPX-DDR4-3000-C15-2x8GB/m43906vs3546
The 4x 4GB is a bit better than 2x 8GB. Where both are total of 16GB, DDR4, 3000 Mhz and