2GB or 4GB on RAM stick?

ss3251

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Feb 3, 2010
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Which is better...
two sticks of 2GB RAM or 1 stick of 4GB RAM?
Is there even a difference?

I am asking because i am looking at a building an machine with an intel i-5 and the board can handle up to 16GB w/ 4 slots. Clearly either way there is room to expand the memory later...