For anything 2666mhz or higher on dual channel architectures, you are better off running two sticks versus four for several reasons.
For one, two sticks presents less of a strain on the CPU/memory controller and motherboard. And for another, running four DIMMs may in some cases limit speed at which you are able to get the memory to run. So, for example, while you might be able to get two sticks to run at 3200mhz, four sticks, depending on the motherboard and the particular memory kit, COULD see a lower speed limitation.
If you don't have to run four DIMMs to achieve the full capacity you are trying to run, on any dual channel motherboard, it is best to not do do so when running high speed DIMMs. If you need to, fine, worst case you...